Association between two functional polymorphisms in the MMP-2 promoter and lung cancer incidence in Asian population: a meta-analysis study

Background: Numerous experiments have been performed to determine the relationship between the Matrix metalloproteinase-2 (MMP-2) -1306C/T and -735C/T polymorphisms and the prevalence and progression of lung cancer in diverse populations. However, due to the small sample size and the different results of previous studies, we decided to perform a general meta-analysis on all previous studies about mmp-2 polymorphism and lung cancer in Asian population. Methods: A complete literature review was conducted within the ISI Web of Knowledge, google scholar, and PubMed databases for studies about MMP-2 polymorphism and lung cancer published from 2002 to 2020. A meta-analysis was conducted, which included more than 2884 cases and 2768 controls. The pooled odds ratio (OR) and 95% confidence intervals (CI) were used for dominant, recessive, and co-dominant MMP-9 genotypes to assess the strength of the association. Results: A significant correlation was found between the MMP2 C 1306T polymorphism and lung cancer risk (C vs T: OR=1.705, P=0.029; CC vs CT+ TT: OR=1.16, 95% P=0.000) and for MMP2 C 735T polymorphism (C vs T: OR=1.433, P=0.151; CC vs CT+TT: OR=1.698, P=0.000). Conclusion: The present meta-analysis revealed a significant association between the MMP-2-735C/T and MMP-9-1562 C/T polymorphisms and the risk of lung cancer in Asian population.